The rhizome (underground extension of the stalk) of picrorhiza has a long history of use in Indian Ayurvedic medicine for the treatment of digestive problems. Other traditional uses include treatment of scorpion sting, asthma, liver diseases, and febrile infections.
There are no scientifically established medicinal uses of picrorhiza.
Picrorhiza is often advocated as a treatment for asthma, based primarily on two studies conducted in the 1970s.1-2 However, neither of these studies was conducted in such a manner as to produce reliable results in the modern sense. Only double-blind, placebo-controlled studies can actually show a treatment effective, and the two such studies of picrorhiza for asthma failed to find the herb more effective than placebo.3,4 (For detailed information on the overwhelming importance of this type of trial, see Why Does This Database Rely on Double-Blind Studies?)
One small, double-blind study found picrorhiza root (375 mg, 3 times daily) more effective than placebo for reducing signs of liver damage in people with acute viral hepatitis.5 However, this study was highly preliminary and suffered from numerous flaws. The other evidence used to support the use of picrorhiza as a liver protectant is even weaker, consisting of test tube and animal studies, and open studies in humans.6
Other proposed uses of picrorhiza that have undergone some study, but at present lack meaningful evidence that they include the following: enhancing response to vaccinations,7 speeding the healing of wounds,8 and enhancing the effectiveness of conventional treatment for vitiligo.9
A typical recommended dose of powdered picrorhiza ranges from 400 mg to 1,500 mg daily, or an equivalent amount in extract form.
Like all plants, picrorhiza contains a variety of chemicals. Some of the more investigated of these constituents include picroside I, kutkoside, androsin, and apocynin. Some picrorhiza extracts are standardized to contain a stated amount of one or more of these substances. However, since no constituent of picrorhiza has any established medicinal benefit, such standardization has no known practical implication.
Based on its long history of traditional use, picrorhiza appears to be relatively safe. However, systematic, scientifically modern safety studies of picrorhiza are lacking. For this reason, we do not at present recommend the use of this herb.
Many herbs and other treatments considered safe based on traditional use have later turned out to present severe, previously unrecognized risks. Herbalists would be expected to notice immediate, dramatic reactions to herbal formulas, and one can assume with some confidence that treatments used for thousands of years are at least unlikely to cause such problems in very many people who take them. However, certain types of harm could be expected to easily elude the detection of traditional herbalists. These include safety problems that are delayed, occur relatively rarely, or are difficult to detect without scientific instruments.
Due to the lack of comprehensive safety evaluation, we strongly recommend against use of picrorhiza by pregnant or nursing women, young children, or people with severe liver or kidney disease.
Rajaram D. A preliminary clinical trial of Picrorrhiza kurroa in bronchial asthma. Indian J Pharmacol. 1975;7:95-96.
Shan BK, Kamat SR, Sheth UK. Preliminary report of use of Picrorrhiza kurroa root in bronchial asthma. J Postgrad Med. 1977;23:118–120.
Dorsch W, Stuppner H, Doshi VB, Shetye VM, Mahashur AA, Kamat SR. Picrorrhiza kurroa in bronchial asthma. J Postgrad Med. 1983;29:89-95.
Thomas M, Sheran J, Smith N, et al. AKL1, a botanical mixture for the treatment of asthma: a randomised, double-blind, placebo-controlled, cross-over study. BMC Pulm Med. 2007;7:4.
Vaidya AB, Antarkar DS, Doshi JC, et al. Picrorhiza kurroa (Kutaki) Royle ex Benth as a hepatoprotective agent—experimental and clinical studies. J Postgrad Med. 1996;42:105-108.
Picrorhiza kurroa. Monograph. Altern Med Rev. 2001;6:319-321.
Khajuria A, Gupta A, Singh S, et al. RLJ-NE-299A: a new plant based vaccine adjuvant. Vaccine. 2007;25:2706-2715.
Singh AK, Sharma A, Warren J, et al. Picroliv accelerates epithelialization and angiogenesis in rat wounds. Planta Med. 2007;73:251-256. Epub 2007 Feb 22.
Bedi KL, Zutshi U, Chopra CL, Amla V. Picrorhiza kurroa, an Ayurvedic herb, may potentiate photochemotherapy in vitiligo. J Ethnopharmacol. 1989;27:347–352.
Last reviewed December 2015 by EBSCO CAM Review Board
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.