Bupropion is an antidepressant, but it is also prescribed to help people quit smoking. It can be used alone or in combination with a nicotine replacement product.
Bupropion appears to affect 2 brain chemicals that may be related to nicotine addiction: dopamine and norepinephrine. Bupropion reduces the cravings for cigarettes that smokers experience when they try to quit. It also seems to reduce many of the nicotine withdrawal symptoms, such as irritability, frustration, and anger.
Your doctor will determine the appropriate level of bupropion for you and will adjust the dosage as you progress.
Tell your doctor about all the medications you take. Some should not be taken with bupropion. For example, you should not take bupropion for smoking cessation if you:
Certain conditions can affect whether it is safe for you to take bupropion. Tell your doctor about your medical history and if you have any health problems, especially if you have:
Other conditions that are important to let your doctor know about include current or history of:
If you are woman who is pregnant or breastfeeding, be sure to talk to your doctor about whether it is safe for you to take bupropion.
Start taking bupropion 1-2 weeks before you plan to stop smoking. This will give the medication enough time to reach adequate levels in your body.
Note: Do not double dose. Taking too much bupropion at one time can cause serious reactions, including seizures.
If all goes well and you are successful in quitting, you should plan to stay on the bupropion for 7-12 weeks. Your doctor may recommend staying on treatment for 6 moths after quitting, depending on your circumstances.
Most people do not have side effects from taking bupropion for smoking cessation. If side effects do occur, they can usually be minimized. In addition, side effects are most often temporary, lasting only as long as you are taking the medication.
There are rare, but serious side effects that you should be aware of. Medications like bupropion may cause severe mood and behavior changes in some people, including suicidal thoughts. Young adults may be more at risk for these side effects. Make sure you call emergency medical services right away if this happens to you.
Common side effects may include:
More serious, but less common side effects may include:
Symptoms of an overdose may be more severe than side effects seen at regular doses, or 2 or more side effects may occur together. Call for emergency medical services right away if you notice any of the following:
Combining bupropion with other medications can increase your risk of seizures, as well as other potentially dangerous interactions. Examples of medications that can cause problems include:
There are many other medications that may interact with bupropion. Be sure to discuss any other medications that you are taking with your doctor.
American Lung Association
Smokefree—National Institutes of Health
Canadian Cancer Society
The Lung Association
Treatment for tobacco use. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed. Updated December 23, 2015. Accessed January 6, 2016.
Bupropion hydrochloride. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed. Updated December 8, 2015. Accessed January 6, 2016.
Prescription medicine: bupropion (Wellbutrin SR, Zyban). Respiratory Health Association website. Available at: http://www.tcyh.org/smoking/downloads/rha/Bupropion.pdf. Accessed January 6, 2016.
Roddy E. Bupropion and other non-nicotine pharmocotherapies. BMJ. 2004; 328(7438): 509-511.
Last reviewed January 2016 by Michael Woods, MD
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.