Hepatitis is inflammation of the liver. Toxic hepatitis refers to inflammation of the liver due to medication or exposure to toxic chemicals. Inflammation is a response by the immune system to an infection, irritation, or injury that often results in swelling and harm to the affected tissue.
A major job of the liver is to process and breakdown foreign substances contained in the blood, including nutrients and chemicals. Some chemicals or drugs that are difficult for the liver to process can damage it, resulting in inflammation.
Some substances associated with toxic hepatitis include:
A risk factor is something that increases your chance of getting a disease or condition. The way the liver processes drugs and chemicals varies from person to person, so not everyone will become sick from the same substance.
However, exposure to large quantities of even minimally harmful toxins, or multiple different toxins simultaneously, can increase the risk of toxic hepatitis. Patients who consume alcohol excessively or have liver disease are at greater risk of toxic hepatitis when exposed to one or more of its causes.
Symptoms of toxic hepatitis include:
There is no specific test to diagnose every case of toxic hepatitis. To make the diagnosis, a doctor will perform a thorough history. Questions will be asked about your use of prescription and over-the-counter medications and any possible chemical exposures, particularly in the workplace.
A physical exam can help determine the size of the liver and any associated tenderness. A blood test can assess how well the liver is functioning. In some cases, your doctor may recommend a liver biopsy to directly assess liver tissue.
There is no medication to treat most types of toxic hepatitis. If a person is diagnosed with this condition, the chemical or drug should be discontinued immediately and avoided in the future. If symptoms are severe, the patient should rest. IV fluid is recommended for people who experience extreme nausea and vomiting.
Symptoms usually go away within a few days or weeks. However, in severe cases, or if the condition was left untreated, toxic hepatitis can lead to irreversible liver failure, which is fatal in the absence of a liver transplant.
Agency for Toxic Substances and Disease Registry
Occupational Safety and Health Administration
Hepatitis C Caring Ambassadors Program
Hepatitis C Education and Prevention Society
Toxic hepatitis. Canadian Liver Foundation website. Available at: http://www.liver.ca/liver-disease/types/toxic-hepatitis.aspx. Accessed May 28, 2013.
Toxic hepatitis. University of California San Francisco Medical Center website. Available at: http://www.ucsfhealth.org/conditions/toxic_hepatitis/. Accessed May 28, 2013.
10/14/2013 DynaMed's Systematic Literature Surveillance http://www.ebscohost.com/dynamed: US Food and Drug Administration. OxyElite Pro: Health advisory—Acute hepatitis illness cases linked to product use. Available at: http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm370857.htm. Published October 8, 2013. Accessed October 14, 2013.
Last reviewed March 2014 by Daus Mahnke, MD
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.