Clonidine is often used to reduce blood pressure as well as to counter symptoms that occur during withdrawal from alcohol and other addictive substances.
There is some evidence that clonidine might impair the body's ability to manufacture the substance coenzyme Q 10 (CoQ 10).1 However, it has not yet been shown that CoQ 10 supplements offer any particular benefit to those taking this medication.
If you are taking clonidine, it is not safe to take yohimbe.2
Kishi H, et al. Bioenergetics in clinical medicine. III. Inhibition of coenzyme Q 10 -enzymes by clinically used anti-hypertensive drugs. Res Commun Chem Pathol Pharmacol 12(3): 533–540, 1975.
Brinker F. Herb contraindications and drug interactions, 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998: 140–141.
Last reviewed December 2015 by EBSCO CAM Review Board
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.