Sarcoidosis is an inflammatory disease that may affect many different parts of the body. Small round spots, called granulomas, form in various organs. The spots slow down normal functioning of those organs.
The cause of sarcoidosis is not known. It seems to be related to malfunctioning of the immune system. The disease may be triggered by an infection or exposure to a toxin in the environment.
Some people may be more susceptible to sarcoidosis due to genetic or environmental factors.
Sarcoidosis is more common in females and at ages 20 to 40 years old. Factors that may increase the chance of sarcoidosis include:
Symptoms vary and can occur in different parts of the body, depending on where the granulomas form. Most symptoms develop in the lungs, skin, eyes, and liver. Multiple body systems may be affected. Symptoms may come and go. This disease is often acute, but in some people, it is chronic.
Symptoms may include:
The doctor will ask about your symptoms and medical history. A physical exam will be done. An eye exam may also be done. There is no specific lab test that confirms a diagnosis of sarcoidosis, but tests may include:
Imaging tests evaluate bodily structures. These may include:
Your heart activity may be tested. This can be done with an electrocardiogram (EKG).
Your lung function may be tested. This can be done with pulmonary function tests (PFTs).
Diagnosis is based on all of the following criteria:
Treatment aims to ease symptoms and minimize permanent problems. Treatment may include:
You need regular medical and eye exams to monitor for symptoms and complications of sarcoidosis.
Drugs that may be prescribed include the following:
To help minimize your symptoms:
American Lung Association
The Arthritis Society
The Lung Association
Explore sarcoidosis. National Heart, Lung, and Blood Institute website. Available at: http://www.nhlbi.nih.gov/health/health-topics/topics/sarc. Updated June 14, 2013. Accessed May 13, 2016.
Sarcoidosis. American Lung Association website. Available at: http://www.lung.org/lung-disease/sarcoidosis. Accessed May 13, 2016.
Sarcoidosis in adults. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed. Updated March 1, 2016. Accessed May 13, 2016.
Sarcoidosis in children. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed. Updated January 28, 2011. Accessed May 13, 2016.
6/14/2016 DynaMed's Systematic Literature Surveillance http://www.ebscohost.com/dynamed: Soto-Gomez N, Peters JI, Nambiar AM. Diagnosis and management of sarcoidosis. Am Fam Physician. 2016;93(10:840-848.
Last reviewed May 2016 by Michael Woods, MD
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.