Alzheimer disease is a chronic, slowly progressive, gradual in onset, irreversible condition that destroys brain nerve cells and other structures in the central nervous system. People with Alzheimer disease slowly develop dementia—a loss of memory and intellectual and social skills that result in confusion, disorientation, and the inability to think, reason, and understand. The decline in cognition and memory results in activities of daily living to be performed with increasing difficulty.
People with Alzheimer disease (and other dementias) have symptoms that can change from day to day. There seem to be occasional times when improvement may be noticed, but over time the disease progressively worsens. The most common symptoms is memory loss.
It has been estimated that over 4 million Americans have Alzheimer disease and the total healthcare costs are estimated to be over $100 billion in the US alone. The number of patients with Alzheimer disease is expected to triple during the next 20 years as the baby boomer generation ages with an associated rise in the economic burden.
Scientists know that Alzheimer disease is caused by damage to brain nerve cells, as well as a loss of certain chemicals that facilitate communication between nerve cells. What is still not clearly understood is why this damage occurs.
Brain autopsies of Alzheimer patients show 2 characteristic brain abnormalities:
Alzheimer dementia. EBSCO DynaMed Plus website. Available at: http://www.dynamed.com/topics/dmp~AN~T114193/Alzheimer-dementia. Updated August 21, 2017. Accessed October 2, 2017.
Alzheimer's disease medications fact sheet. National Institute on Aging website. Available at: https://www.nia.nih.gov/alzheimers/publication/alzheimers-disease-medications-fact-sheet. Updated May 18, 2017. Accessed October 2, 2017.
What is Alzheimer's? Alzheimer’s Association website. Available at: http://www.alz.org/alzheimers_disease_what_is_alzheimers.asp. Accessed October 2, 2017.
Last reviewed September 2017 by EBSCO Medical Review Board Rimas Lukas, MD
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