Blood poisoning, also called septicemia or sepsis, is the presence of an infection or its toxin spreading through the bloodstream.
The presence of bacteria in the blood is called bacteremia. Short bursts of low levels of bacteria in the blood usually do not cause problems.
Sepsis occurs when large numbers of infectious agents exist in the blood. Infections with viruses, fungi, and parasites may lead to sepsis as well. The body responds by trying to fight the infection. Causes include:
This condition is more common in older adults, especially those with frail health. Factors that increase your chance of getting sepsis include:
The first symptoms depend on the site of the infection.
As the condition progresses to sepsis, symptoms may include:
You will be asked about your symptoms and medical history. A physical exam will be done. If sepsis is suspected, the source of the infection will attempt to be found.
Your bodily fluids and waste products may be tested. This can be done with:
Images may be taken of your bodily structures. This can be done with:
This condition will need to be treated aggressively. Treatment is aimed at the cause of the initial infection.
Early treatment improves the chance of survival. Life-saving steps may be needed to assist breathing and heart function. People with sepsis usually need to be observed in an intensive care unit.
IV antibiotics will be used to fight a bacterial infection and to clear it from your blood. You may be given oral antibiotics when you leave the hospital.
You will likely receive other medications, IV fluids, and oxygen. If your blood pressure remains too low, you may need vasopressors—medications to help maintain your normal blood pressure. Blood transfusions and a respirator to help you breathe may be necessary in some cases.
Further treatment depends on how your body is responding. For example, you may need kidney dialysis if kidney failure occurs.
Centers for Disease Control and Prevention
Infectious Diseases Society of America
Public Health Agency of Canada
Early-onset neonatal sepsis. EBSCO DynaMed Plus website. Available at: http://www.dynamed.com/topics/dmp~AN~T901439/Early-onset-neonatal-sepsis. Updated August 11, 2016. Accessed September 29, 2016.
Late-onset neonatal sepsis. EBSCO DynaMed Plus website. Available at: http://www.dynamed.com/topics/dmp~AN~T116619/Late-onset-neonatal-sepsis. Updated August 11, 2016. Accessed September 29, 2016.
Sepsis in adults. EBSCO DynaMed Plus website. Available at: http://www.dynamed.com/topics/dmp~AN~T115805/Sepsis-in-adults. Updated June 8, 2016. Accessed September 29, 2016.
Sepsis in children. EBSCO DynaMed Plus website. Available at: http://www.dynamed.com/topics/dmp~AN~T326289/Sepsis-in-children. Updated October 22, 2015. Accessed September 29, 2016.
10/6/2014 DynaMed Systematic Literature Surveillance http://www.ebscohost.com/dynamed: Holland TL, Arnold C, et al. Clinical management of Staphylococcus aureus bacteremia: a review. JAMA. 2014 Oct 1;312(13):1330-41.
Last reviewed May 2016 by David Horn, MD
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.