Deep vein thrombosis (DVT) is a blood clot in a vein deep in the body. Veins are blood vessels with valves that help prevent backward blood flow. Blood is pushed through the veins in legs and arms when muscles contract.
Deposits of red blood cells and clotting elements in the blood can build up in a vein. This build up leads to a blood clot. Clots usually occur in the legs, but can occur in other locations. As the clot grows, it blocks blood flow in the vein.
Several factors contribute to clot formation, including:
Risk factors for DVT include:
Symptoms occur when:
Some patients may not have any symptoms until the clot moves to the lungs. This condition is called pulmonary embolism.
Symptoms of DVT may include:
The doctor will ask about your symptoms and medical history. A physical exam will be done.
Treatment aims to:
This may include:
You may be prescribed blood thinning medication to prevent additional clots from forming. These may be given by injection or by mouth. This treatment may be continued long-term.
General prevention measures include:
If you are admitted to the hospital, talk to your doctor about how to prevent blood clots, such as:
American Heart Association
American Venous Forum
Heart and Stroke Foundation of Canada
Buller HR, Agnelli G, Hull RD, et al. Antithrombotic therapy for venous thromboembolic disease: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest. 2004;126(suppl 3):401S-428S.
Deep vein thrombosis (DVT). EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed. Updated May 2, 2013. Accessed May 7, 2013.
Geerts WH, Pineo GF, Heit JA, et al. Prevention of venous thromboembolism: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest. 2004;126(suppl 3):338S-400S.
Hirsch J, Hoak J. Management of deep vein thrombosis and pulmonary embolism. Circulation. 1996;93(12):2212-2245.
Ramzi DW, Leeper KV. DVT and pulmonary embolism: Part I. Diagnosis. Am Fam Physician. 2004;69(12):2829-2836.
Ramzi DW, Leeper KV. DVT and pulmonary embolism: Part II. Treatment and prevention. Am Fam Physician. 2004;69(12):2841-2848.
Segal JB. Streiff MB. Hoffman LV. Thornton K. Bass EB. Management of venous thromboembolism: a systematic review for a practice guideline. Ann Intern Med. 2007;146(3):211-222.
10/27/2006 DynaMed's Systematic Literature Surveillance http://www.ebscohost.com/dynamed: Junger M, Diehm C, Storiko H, et al. Mobilization versus immobilization in the treatment of acute proximal deep venous thrombosis: a prospective, randomized, open, multicentre trial. Curr Med Res Opin. 2006;22:593-602.
5/11/2009 DynaMed's Systematic Literature Surveillance http://www.ebscohost.com/dynamed: Bezemer ID, van der Meer FJ, Eikenboom JC, Rosendaal FR, Doggen CJ. The value of family history as a risk indicator for venous thrombosis. Arch Intern Med. 2009;169:610-615.
6/4/2010 DynaMed's Systematic Literature Surveillance http://www.ebscohost.com/dynamed: Bahl V, Hu HM, Henke PK, Wakefield TW, Campbell DA Jr, Caprini JA. A validation study of a retrospective venous thromboembolism risk scoring method. Ann Surg. 2010;251(2):344-350.
10/5/2010 DynaMed's Systematic Literature Surveillance http://www.ebscohost.com/dynamed: Parker C, Coupland C, Hippisley-Cox J. Antipsychotic drugs and risk of venous thromboembolism: nested case-control study. BMJ. 2010;341:c4245.
7/1/2014 DynaMed's Systematic Literature Surveillance http://www.ebscohost.com/dynamed: Tepper NK, Boulet SL, et al. Postpartum venous thromboembolism: incidence and risk factors. Obstet Gynecol. 2014 May;123(5):978-996.
Last reviewed March 2014 by Michael J. Fucci, DO
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.